Author: Hannah

  • Everyday tales of trauma

    Everyday tales of trauma

    A young woman who lost half her blood in a terrifying car crash, and lived. A man with a fractured skull from a simple fall on his stairs. A crack team of nurses, surgeons and specialists on call 24/7. Welcome to the daily drama of the region’s trauma HQ.

    It was late on a Thursday afternoon in early December last year. Santanna and her mother-in-law had just finished installing a set of holiday flower arrangements at a client’s house in King Township, near Nobleton, Ont. The pair planned to fit in one more client visit before Santanna met her husband Dan for a dinner date.

    As they turned out of the driveway, their truck collided with another car. Though both vehicles were badly damaged, no one was seriously injured. While Santanna waited for the police to turn up, Santanna’s husband and her father-in-law arrived.

    About 40 minutes later, without warning, another car cleared the corner, slid on the ice and spun. It was followed by a black truck that swerved to avoid the car. It too struck the ice, hit Santanna and tossed her through the air. The truck then ran over her and dragged Santanna about four metres before it came to rest, with her buried in the snow under its rear wheels.

    “The last thing I remember is being underneath the truck and having Dan dig me out. He was crying and freaking out. I said, ‘I love you, and ‘goodbye’,” recalls Santanna. “I didn’t think I was going to make it.”

    Santanna owes her survival to a set of coincidences, some quick thinking by an off-duty emergency physician and a first-rate trauma team at Sunnybrook.

    The crash took place not far from the home of a pair of Sunnybrook doctors. Dr. Valerie Krym was outside, cleaning snow off the steps of their house when her husband telephoned. He is the Medical Director at ORNGE, the transport medical service provider for the province of Ontario, and was on duty in ORNGE’s Communication Centre that evening. He’d heard about the crash and called home to check on his wife.

    By now it was dark. The ORNGE helicopter did not land at the scene because these landings are not safe to do at night, and there wasn’t a nearby helipad or airport available. A land ambulance was dispatched and already en route to the scene.

    Dr. Krym, an emergency physician at Sunnybrook, walked to the end of her long driveway. The crash scene was a kilometre away and Dr. Krym’s car was in the shop, but because there were so many emergency vehicles on the scene she decided to walk there.

    When Dr. Krym arrived, she saw that Santanna was critically injured—her pelvis and lower legs were crushed and one of the major blood vessels in one of her legs had opened up. Her blood pressure was very low. Sunnybrook was not the closest hospital, but “I knew it was her only chance of survival. She needed a trauma centre,” recalls Dr. Krym. “While we were speeding down the 401, I told the driver to notify Sunnybrook’s trauma team and tell them to be ready and waiting for us in the trauma room for our arrival.”

    Santanna’s injuries were so severe, the health care team didn’t think she would live. “The injuries were clearly horrific and life threatening. She’d lost more than half her blood,” says Dr. Doreen Yee, the trauma team leader who directed Santanna’s care that night.

    ———————–

    Sunnybrook’s Tory Regional Trauma Centre provides care for patients suffering from a wide range of traumatic injury from motor vehicle collisions, stabbings and gunshot wounds, cycling and other recreational activities, and falls in the GTA and south central Ontario.

    When Sunnybrook receives notice that a trauma is en route, it activates an internal network that draws the on-call trauma team composed of anaesthesiologists, orthopaedic surgeons, general surgeons, neurosurgeons, respiratory therapists and nurses to the trauma centre.

    On a Monday afternoon in late February, Heather Mazurenko, a registered nurse, picks up the receiver of the red phone on the nurses’ desk in the emergency department. “How far out are they?” she asks the dispatcher. A screen mounted on a nearby wall has begun to flash. An older man has fallen down the stairs at his home and hit his head. EMS has scored the injury a level 2 out of 5 on the Canadian Triage and Acuity Scale, where 1 is the most severe.

    “It’s coded as a trauma, so they’ll come to the nearest trauma centre, which is us. We’ll treat it as such until we know what’s going on,” says Ms. Mazurenko, taking off her glasses. It’s just after 5 p.m. and nearly 10 hours into her shift. As the scheduled Clinical Care Leader, Ms. Mazurenko’s role is to manage the movement of patients through the hospital’s emergency department and its health care staff. “I need to know where everyone is and what beds are available. I run around all day—I’m the rabbit. That’s why I have lunch at 7 p.m.,” she says. When the ambulance is on its way to Sunnybrook she pages the trauma surgical team. Most traumas will reel in seven staff; a major trauma will draw in closer to 10.

    At 5:40 p.m. four paramedics wheel the patient stretcher into the trauma room, a large open space with four trauma bays. Metal storage racks stacked with blue boxes stocked with syringes, gloves and other medical supplies line one wall. A low fridge tucked against the opposite wall holds blood. A Kodak Direct View DR 95000 system X-ray machine is suspended from the ceiling.

    The man is intubated, hooked up to an intravenous line, sedated and attached to a portable monitor that measures his heart rate, blood pressure and blood oxygen levels. Dr. Paul Engels, the on-call trauma team leader, leans over the table and rubs his knuckles into the centre of the man’s chest.

    At the scene of the crash, the man had scored an 11 on the Glasgow Coma Scale, which assesses a patient’s eye, verbal and motor responses following a head injury. The pain response was a good sign, but the patient’s score had dropped to a five, and considered severe. “Pupils are 2, and reactive bilaterally,” says Dr. Engels.

    Dr. Sebastian Tomescu, the on-call orthopaedic resident, runs his hands along the man’s legs and flexes his knees and rotates each hip, checking for broken and dislocated bones. He moves quickly, finding no injuries.

    The team of seven rolls the man onto his side so that Dr. Tomescu can check his spine. Amidst the chatter, the beeps and the pings, there are the sounds of the patient’s flannel shirt ripping and metal hitting the floor as his belt and pants are dropped. Discarded packaging and medical tape accumulate around the stretcher. A kidney-shaped tray holds the patient’s dentures. They remove the neck brace, staple shut the laceration over the man’s right ear, and roll him back. “Let’s do a chest and a pelvis X-ray,” says Dr. Engels. It’s 5:59 p.m.

    Less than 10 minutes later, the room is noticeably calmer and quieter. The trauma team continues to check the patient’s vitals noting the numbers in his chart, and tidy up the tubes and wires that connect him to the IV bags and machines, before he is wheeled a short distance down the hall to the trauma centre’s dedicated CT scanning room.

    Ten staff lift the man from the stretcher to the narrow CT table to scan for bleeds and breaks. Dr. Martin Shoichet, a radiologist, spreads his elbows wide and leans on the desk peering at the computer screen in front of him. He spots a crescent-shaped sliver of blood between the brain and the skull. “There’s also a rib fracture, and probably a small hemothorax [blood in the chest cavity], maybe two,” says Dr. Shoichet. Dr. Engels picks up the phone and books an operating room.

    Ginny Cosby, a registered nurse on the trauma team, pops into the room to speak to Dr. Engels. “I’ve told the family he’s critical and that you’ll come to see them. I put them in the family room. They’re a little anxious,” she says.

    A minute later, Ms. Mazurenko leans into the room, phone tucked under her ear. “I’ve got an OR,” she says. The trauma team stops the scan and moves the patient onto the elevator to take him up to an operating room. It’s 6:51 p.m.

    Back at the nursing station in the Emergency Department, staff dressed in jackets and carrying coffee begin streaming in and study a large white board to find their assignment for the night. There are two minutes left in Ms. Mazurenko’s shift and she has yet to eat her lunch. The red phone rings. She picks it up. “Tell me, what’s on the ticket?” she asks.

    ———————–

    Santanna’s heart stopped while she was in the CT scanner. “When people’s hearts stop because of blood loss, it is not easy to get them back,” says Dr. Yee. The team did CPR and gave Santanna epinephrine to keep her alive and rush her up to the OR. “I had an excellent trauma team that night, we were a well-oiled machine,” she says. “Dr. Krym made a good decision to bring Santanna to Sunnybrook and not waste time going to one of the smaller hospitals that might not have had the resources to help her,” says Dr. Yee.

    Santanna’s pelvis was crushed. The doctors amputated her left leg above the knee and performed a through-the-knee amputation on her right leg. But she is alive. Three months after the accident, Santanna remains in a rehabilitation hospital receiving occupational and physical therapy daily. “My goal is to get my prosthetic legs, so I can get back on my horses. I miss my animals so much,” she says. Santanna’s other goal is to have a helipad built in the Nobleton region so that other trauma victims don’t face the same risks she did. “If it wasn’t for Dr. Krym, I wouldn’t be here,” says Santanna.

    Published in the Globe and Mail as a special informational supplement on Sunnybrook.

  • The numbers don’t lie

    The numbers don’t lie

    The day before Barry Shiffman was to fly from Toronto to Russia to begin serving on the Violin Jury of the International Tchaikovsky Competition, the 44-year-old learned he had prostate cancer.

    “I was floored by the diagnosis. I sat for in the lobby of Sunnybrook for two-and-a-half hours thinking, ‘What is happening?’” recalls Barry, who is the associate dean of the Glenn Gould School at the Royal Conservatory of Music, and father of two. “But once you get over the insanity, the realization, that you have cancer, then you think, ‘I am so lucky. It could have easily been missed’,” he says.

    When Barry moved with his family to Toronto from Banff, Alberta in 2010, he thought he had his health under control. He had been previously diagnosed with a benign enlarged prostate, the harmless growth of the prostate often associated with aging. As a precaution, Barry had his PSA levels checked routinely, to rule out the possibility of prostate cancer.

    The adult prostate gland makes a protein called prostate specific antigen (PSA). A healthy prostate releases small amounts of the protein into the blood, but prostate cancer will often increase its production. Men with PSA levels greater than 4 nanograms per millilitre of blood may be offered a needle biopsy to check the prostate for cancer.

    In December, Barry’s PSA test came back higher than normal. His physician consulted with Sunnybrook’s Dr. Robert Nam, a urologic oncologist at the Odette Cancer Centre, and researcher behind a new online tool that provides a better assessment of prostate cancer risk. It helps patients avoid unnecessary prostate biopsies, but it can also detect prostate cancer at an earlier, more curable stage, and identify high-risk patients.

    Dr. Nam developed the risk calculator when he realized that the PSA blood tests doctors use to screen for prostate cancer were no longer reliable. “When it was introduced 20 years ago it was a fabulous test. It caught all the cancers out there. But it couldn’t detect the low volume prostate cancers—the new cases that were just starting out and didn’t have enough cancer cells to crank up that PSA. But then we realized that we knew a lot about the established risk factors for prostate cancer,” Dr. Nam says.

    Unlike the standard approach, the new calculator (also called a nomogram) considers age, ethnicity, family history of prostate cancer and urinary symptoms when calculating a man’s prostate cancer risk. Dr. Nam and his colleagues developed and checked the risk calculator with over 3,100 Canadian men, including 408 men with normal PSA levels. It worked better than conventional screening methods. Nearly a quarter of the men with a normal PSA were diagnosed with prostate cancer.

    “The calculator empowers the patient. They still control what they want to do, but it gives them more information to make their decision,” says Dr. Nam. “That’s the bottom line.”

    “I haven’t cancelled my plans for the summer,” says Barry. “My treatment plan doesn’t include chemo or radiation, but I will have surgery in April. Hopefully I’ll be back to life as I know it soon.”

    Published in the Globe and Mail as a special informational supplement on Sunnybrook

  • Despite Canadian government woes, neuroscience should win out

    Despite Canadian government woes, neuroscience should win out

    MONTREAL — When Canada’s Conservative government presented its 2011 budget in late March, the fiscal plan didn’t contain too many surprises for science funding. Like previous budgets, the proposal offered modest increases to the country’s national research agencies and replenished the coffers of Genome Canada, its genomics and proteomics outfit. But the budget also contained a flashy and unprecedented new move: a multimillion-dollar earmark for neuroscience research.

    Under the Conservatives’ proposed scheme, the government would contribute up to C$100 million ($105 million) over several years to the Canada Brain Research Fund, a public-private partnership led by the Brain Canada Foundation in collaboration with the Canadian Association for Neuroscience and Neurological Health Charities Canada (NHCC). The government money would then be matched by funds raised from private sources by Brain Canada to support large, multidisciplinary neuroscience grants, postdoctoral fellowships and training programs.

    Read the full story at Nature Medicine(subscription required). Published online 5 May 2011.

    Magnetic Resonance Imaging scan of a head. Released under the GFDL by en:User:TheBrain on 20 May 2003.

  • Canadian research shift makes waves

    Canadian research shift makes waves

    McDougallNRC

    Agency’s focus on industry-driven projects raises concerns that basic science will suffer.

    Published in Nature, 19 April 2011.

    Canada’s largest research entity has a new focus — and some disaffected scientists. On 1 April, the National Research Council (NRC), made up of more than 20 institutes and programmes with a total annual budget larger than Can$1 billion (US$1 billion), switched to a funding strategy that downplays basic research in favour of programmes designed to attract industry partners and generate revenue. Some researchers suggest that the shift is politically driven, because it brings the agency into philosophical alignment with the governing Conservative Party of Canada, which is in the middle of an election campaign.

    The change was announced in a memo from NRC president John McDougall on 2 March, and involves the transfer of authority over 20% of the agency’s research funds and the entire Can$60-million budget for large equipment and building costs to the NRC’s senior executive committee, which will direct it towards research with a focus on economic development, rather than pure science. Until now, individual institutes have had authority over research spending. McDougall wrote that in future, 80% of the research budget will be centralized, with “curiosity and exploratory activities” to be funded by the remaining 20%.

    In Canada, most funding for academic researchers flows through agencies other than the NRC. However, with 4,700 scientists, guest researchers, technologists and support staff pursuing specialities from astrophysics to plant biotechnology at its institutes, the NRC plays a vital part in the nation’s scientific community, as a generator of original research and a service provider to government and industry. The shift away from basic science “weakens” the NRC’s labs, because they “are required to bridge two cultures — the basic and applied”, says John Polanyi, a Nobel laureate and a chemist at the University of Toronto.

    But in a follow-up memo on 24 March, McDougall said “most ‘researcher directed’ and basic work is now carried out in academic institutions. Duplicating the efforts of universities at NRC doesn’t make much sense.”

    Four proposed ‘flagship programmes’ described in the original memo, each with a marketable outcome, provide a glimpse at the direction the agency has in mind. They include developing a strain of wheat resilient to environmental stress; improving the manufacture of printable electronics; increasing domestic production of bio composite materials; and using algae to soak up carbon dioxide emissions from industry. NRC researchers have expressed concern that jobs and programmes that do not fit with the new agenda are at risk. The agency declined to comment.

    Tom Brzustowski, who studies commercialization of innovation at the University of Ottawa, says that the adjustment to the NRC’s focus will support areas that have been weak. “By focusing on the flagship programmes there is still room to do the whole spectrum of research. It’s a good strategic move,” he says.

    But the news has rekindled anxiety over how Canada’s government has been directing science funding — criticisms that have grown sharper as the federal election on 2 May approaches.

    On 22 March, the government presented its 2011 budget, which offered modest increases to the federal research councils, but did not make up for cuts in 2009 (see Nature 457, 646; 2009). The budget also included multi million-dollar investments in neuroscience and physics. Few question the quality of work that such investments would produce, but critics say that the government is exerting too much control over the country’s research, rather than allowing peer review to guide funding.

    “It’s risky to divert funds away from the granting councils, but the government does it because it looks politically better for them,” says Robert Dunn, associate director of scientific affairs at the Montreal Neurological Institute. “Peer review is the very best mechanism to ensure that the limited research resources we have are allocated to the best researchers and projects.”

    Photo: NRC Canada

  • Think small

    The Canadian forestry industry could hinge on the most abundant nanomaterial on earth.

    A pale grey slurry roils about in a waist-high blue plastic drum at the centre of a garage-like space at the National Research Council’s Biotechnology Research Institute in Montreal. It looks a little like slush, but when it is dried it more closely resembles one of the fine white powders chefs stock in their kitchens. For the handful of chemists hovering about the room, it’s the stuff dreams are made of. For Canada’s faltering forestry industry, it is a beacon of optimism.

    Nanocrystalline cellulose (NCC) is nature’s Superman fibre; it is stronger than steel, lightweight and durable; its unique optical qualities make it desirable for use in everything from cosmetics and sunscreens to security documents, switchable optical filters, coatings and adhesives, and its anti-microbial properties open the door for a bunch of medical applications. All that from a little crystal made from tree trunks.

    It’s no surprise then that the Canadian forestry industry–straining under a slumped U.S. housing market and pricing pressures from developing countries–has high hopes that this possibly miraculous crystal will be their ticket to stage a much-needed comeback. The question now is, can this superhero compound make the leap from the lab, to large-scale production and into the marketplace?

    Read more in the April 2011 issue of Canadian Chemical News.