Author: Hannah

  • Why blog? Because it’s the best job, ever

    Thanks to a grant from the National Association of Science Writers, the New England Science Writers has made their Jan. 19 presentation on health & science blogging freely available online.

    The panel featured:

    For more details and links, visit: http://neswonline.com.

    And a write up by organizer and freelance journalist Carol Cruzen Morton on her blog Gravity Surfing.

  • Bill to help Canadian companies ship generics has uncertain future

    Bill to help Canadian companies ship generics has uncertain future

    From Nature Medicine. Published online 7 March 2011.

    Backed by nongovernmental organizations and the generics industry, the left-of-center New Democratic Party has championed a bill that set out to improve Canada’s Access to Medicines Regime (CAMR), a law that enables drug manufacturers in the country to make generic medications for shipment to developing countries to treat illnesses such as tuberculosis and AIDS. The bill, C-393, was introduced to the House of Commons in 2009 and aimed to eliminate many of the CAMR procedures that its supporters consider unwieldy and extend the list of eligible drugs. But the bill has been so gutted that many global health advocates say they cannot support it in its current state, and it is floundering in Canada’s parliament.

    Under the existing legislation, generic manufacturers that are unable to negotiate a voluntary license from the patent holders can ask the Canadian Commissioner of Patents for a compulsory license to produce an eligible product to address public health problems in another country. If the commissioner says yes, the law then authorizes a one-time license for a named product, along with the country to which it is to be shipped and order size.

    Read the full article at Nature Medicine (subscription required).

    Photo by Takkk.

  • The painted brain: how our lives colour our minds

    The painted brain: how our lives colour our minds

    The brain arrives shortly after lunch.

    It rests on the lab bench, in a Styrofoam box plastered with “Urgent Delivery” and “Fragile” stickers, while two research assistants prepare the dissection laboratory. One has tuned a small radio to a classical station. The sounds of bassoons and strings waft into the room. The opus is an allegro – upbeat and quick.

    The technicians glide around the room with practised coordination. They are cloaked in knee-length blue plastic aprons, sleeves tucked into latex gloves. They tape absorbent mats to the bench tops and lay out scalpels and forceps.

    Josée Prud’homme adjusts her face mask and eye shield, and nods to her colleague, Maâmar Bouchouka.

    Bouchouka lifts the red biohazard bag from the box and slices it open with a scalpel.

    “We’re starting. It’s 13:21,” he says.

    He pats the brain down with paper cloths and sets it on a white cutting board. It slouches a bit. The tissue has started to break down. The brain is pink and a little shiny. Dark red blood vessels snake through the deep wrinkles and folds of the cerebral cortex, like rivers through weathered canyons.

    It’s the brain of someone who took his life over the weekend, and was donated to the Quebec Brain Bank shortly thereafter.

    “It’s very emotional, each time we receive a brain at the bank. We don’t get used to death,” says Prud’homme.

    For 90 minutes, Bouchouka and Prud’homme will remove and freeze the brain’s key structures. They’ll separate the two hemispheres, preserving one in a rectangular clear plastic container filled with a formaldehyde solution, and cutting the other into one-centimetre-thick slices flash-frozen for storage at minus 80 degrees Celsius.

    Now named S-252, this brain has become a critical resource for scientists interested in the biological and environmental underpinnings of mental illness. (more…)

  • Cancer drugs should add months, not weeks, say experts

    From Nature Medicine. Published online 7 January 2011.

    In the last decade, the world’s drug regulatory agencies have approved dozens of new anticancer therapies for everything from lung carcinoma to skin melanoma. Some of these new drugs add months to a patient’s life. But others may offer only an extra week or two, on average, often with considerable toxicity and at a cost of thousands of dollars.

    Now experts are questioning whether these outcomes provide meaningful benefit to people’s quality of life and are urging regulatory agencies to toughen the criteria for drug approval. Such a measure would push pharmaceutical companies to modify the design of clinical trials—a move that some drug makers and doctors worry could shrink the drug market.

    Read the full article at Nature Medicine (subscription required).

  • Banking on biodiversity

    Banking on biodiversity

    The diversity of life on Earth gives ecosystems the resilience they need to thrive. Yet every day scores of plants and animals go extinct, victims of activities we humans undertake to feed, clothe, house and trans­port ourselves. How can we meet our own needs without destroying that which sustains us?

    The west coast of Vancouver Island in British Columbia, Canada, has a rugged, involuted shoreline, etched by fjords, sand dunes and shel­tered coves. It is sandwiched between two biospheres, the dark swelling sea and the emerald temperate rain forest, and it attracts all sorts—from salmon to surfers.

    As idyllic as it seems, the island is under pressure. Wild salmon populations seem to ebb and flow unpredictably, and logging, transporta­tion and aquaculture—activities that promise economic prosperity for the people who live here—are chipping away at the natural coastal ecosystem and the species it contains.

    The tug-of-war between opposing priorities—the conservation of natural assets and de­velopment—poses a challenge for West Coast Aquatic, the public-private partnership in charge of creating a marine spatial plan for the 285-mile-long shoreline. How to lay out a plan that allows the area to develop while preserving its natural resources, ecosystems and habitat?

    This balance of development and conservation is a challenge wherever people are found. At its core is the ability to understand and factor in the true impact—economic and otherwise—of human activity, whether it’s shipping, aquaculture or recreation, on the environment. Would con­struction of an offshore wave energy installation cut into revenues brought in by recreation? If so, by how much? Is it worth it? What effect would expansion of aquaculture have on native finfish and shellfish? At what price to ecosystem (and economic) integrity?

    For West Coast Aquatic, the answers may come from “SimCity”-like software that can illustrate the impacts of different scenarios on human well-being and biodiversity.

    Called Marine InVEST, the software considers a region’s underwater topography, native habitats, species distribution, fishing practices, aquaculture sites, coastline features (such as dunes and sea grasses), wave height and periodicity, and recreational activities. Once those data have been collected, Marine InVEST can calculate the outcomes of a variety of scenarios, such as establishing a protective area or shellfish aquaculture sites.

    “The tool is flexible in terms of outputs, whether it’s in meters of shoreline not eroded or pounds or number of fish—or dollars,” says Anne Guerry, lead scientist for the project’s marine initiative.

    The west coast of Vancouver Island is the first demonstration site of Marine InVEST by the Natural Capital Project, a partnership among Stanford University, The Nature Conservancy, World Wildlife Fund, and the University of Minnesota’s Institute on the Environment.

    “In the past, we didn’t think too much about the spatial overlap of marine activities. We tended to think of them in silos,” says Guerry. “A tool like Marine InVEST allows us to make clear connections between different activities, so we can understand and value each one and how emphasizing one can come at the cost of another.”

    The group plans to use Marine InVEST in other demonstration sites around the world, including Belize, Puget Sound, Chesapeake Bay and Galveston Bay.

    Already, governments, nongovernmental organizations and scientists at universities and institutes in Indonesia, Hawaii, Tanzania, Colom­bia, Ecuador and China are adopting InVEST, the Natural Capital Project’s land-focused companion to Marine InVEST, in their decision making. In the East Cauca Valley, Colombia, The Nature Conservancy and ASOCAÑA, an association of sugarcane producers, formed a water fund called Fondo de Agua por la Vida y la Sostenibilidad (Water Fund for Life and Sustainability) to invest in key areas to keep the water sediment-free and available. The group then used InVEST to map carbon storage, habitat quality and soil stabiliza­tion within the region—showing, for example, where the group should invest in reforestation or in fencing off an area, while taking into account the communities that live within the watersheds.

    “Spatial mapping [like InVEST] lets us map out impacts, letting stakeholders better view and understand impacts and trade-offs,” says Ken Bag­stad, a postdoctoral associate at the University of Vermont. Bagstad is applying InVEST models for water, carbon, biodiversity and cultural services to the exceptionally biodiverse San Pedro River watershed in southeastern Arizona. Home to one of the last free-flowing rivers in the Southwest and a key bird migration corridor, the region is struggling to balance the water needs of the com­munity with the riverbank ecosystem. Bagstad is using InVEST and another mapping tool, ARIES, to test several scenarios, including an option that would restore an invasive mesquite shrubland to native grasslands. The main challenge of using such tools, says Bagstad, is that they are still in their infancy and require some more work before they can be considered a generalized global tool.

    The Planet’s Heartbeat

    Biodiversity is the measure of the variety of life. It is the seed from which all ecosystems spring. It is the foundation of the wetlands that purify water and offer protection against floods, the forests that capture carbon dioxide from the atmosphere and store it in biomass, and the coral reefs that offer breeding grounds for fish. Biodiversity provides societies with goods—food, fuel, fiber and medicinal plants—and services—erosion control, hydropower, cultural significance, recreation, carbon sequestration. Clean air, Vermont maple syrup, opportunities to ice fish, plant-sustaining soil and much more all trace back to thriving living things. Each species is like a spot of paint in one of Seurat’s pointillist masterpieces—an element of the whole picture.

    Environmentalists Tina Fujikawa and Joseph Dougherty recently wrote, “Monitoring trends in biodiversity is like listening to the heartbeat of the planet.” If so, the planet’s pulse is weak and sluggish. Many of Earth’s mammal, bird and amphibian species—10 to 30 percent—are threatened with extinction due to human activities. Some, like corals, which have long been identified as extinction risks, are moving closer to extinction, and ecosystems continue to deteriorate and be splintered apart. Scientists say that if current trends endure, societies could suffer heavy consequences.

    In a 2009 article in Nature, an international group of scientists and economists led by Johan Rockström of the Stockholm Resilience Centre at Stockholm University identified and quantified nine planetary boundaries—from climate change and ocean acidification to global fresh water use and biodiversity loss. These boundaries map out humanity’s safe operating space on Earth. Species loss, the group acknowledged, was a natural process, albeit one that has acceler­ated under human influence. If the extinction rate could be kept at or below 10 species per million species per year, they reasoned, the Earth’s ecosystems might survive. Alas, the current rate is 10 times the goal. For biodiversity loss, the planetary boundary has been exceeded.

    Continue reading the article in Momentum, the magazine of the University of Minnesota’s Institute on the Environment.